1RCV

Cholera Toxin B-Pentamer Complexed With Bivalent Nitrophenol-Galactoside Ligand BV1

Summary for 1RCV

• Entry DOI: 10.2210/pdb1rcv/pdb
• Related: 1RD9 1RDP 1RF2
• Descriptor: cholera toxin B protein (CTB), [3-(4-{3-[3-NITRO-5-(GALACTOPYRANOSYLOXY)-BENZOYLAMINO]-PROPYL}-PIPERAZIN-1-YL)-PROPYLAMINO] -2-(3-{4-[3-(3-NITRO-5-[GALACTOPYRANOSYLOXY]-BENZOYLAMINO)-PROPYL]-PIPERAZIN-1-YL} -PROPYL-AMINO)-3,4-DIOXO-CYCLOBUTENE (3 entities in total)
• Functional Keywords: bivalent, cholera, toxin, pentamer, complex
• Biological source: Vibrio cholerae
• Cellular location: Secreted: P01556
• Total number of polymer chains: 5
• Total formula weight: 63782.14

Authors

Pickens, J.C.,Mitchell, D.D.,Liu, J.,Tan, X.,Zhang, Z.,Verlinde, C.L.,Hol, W.G.,Fan, E. (deposition date: 2003-11-04, release date: 2004-10-26, Last modification date: 2011-07-13)

• Primary citation: Pickens, J.C.,Mitchell, D.D.,Liu, J.,Tan, X.,Zhang, Z.,Verlinde, C.L.,Hol, W.G.,Fan, E.; Nonspanning bivalent ligands as improved surface receptor binding inhibitors of the cholera toxin B pentamer.; Chem.Biol., 11:1205-1215, 2004; PubMed: 15380181; DOI: 10.1016/j.chembiol.2004.06.008

Experimental method

X-RAY DIFFRACTION (1.6 Å)