1RAZ

THE STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH BROMIDE AND AZIDE

Summary for 1RAZ

Entry DOI	10.2210/pdb1raz/pdb
Descriptor	CARBONIC ANHYDRASE II, ZINC ION, BROMIDE ION, ... (4 entities in total)
Functional Keywords	lyase(oxo-acid)
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm : P00918
Total number of polymer chains	1
Total formula weight	29303.18
Authors	Jonsson, B.M.,Hakansson, K.,Liljas, A. (deposition date: 1993-04-02, release date: 1993-10-31, Last modification date: 2024-02-14)
Primary citation	Jonsson, B.M.,Hakansson, K.,Liljas, A. The structure of human carbonic anhydrase II in complex with bromide and azide. FEBS Lett., 322:186-190, 1993 Cited by PubMed Abstract: The three-dimensional structure of human carbonic anhydrase II complexed with azide and with bromide was investigated crystallographically. Both of these non-protonated inhibitors replace the zinc and the 'deep' water, two catalytically important water molecules in the active site of the molecule. Both the azide and the bromide ions bind in a distorted tetrahedral manner 0.4 and 1.1 A from the zinc water position, respectively, but are in close contact (2.0 and 2.6 A, respectively) with the zinc ion. PubMed: 8482389 DOI: 10.1016/0014-5793(93)81565-H PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation