1RAZ

THE STRUCTURE OF HUMAN CARBONIC ANHYDRASE II IN COMPLEX WITH BROMIDE AND AZIDE

1RAZ の概要

• エントリーDOI: 10.2210/pdb1raz/pdb
• 分子名称: CARBONIC ANHYDRASE II, ZINC ION, BROMIDE ION, ... (4 entities in total)
• 機能のキーワード: lyase(oxo-acid)
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm : P00918
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29303.18

構造登録者

Jonsson, B.M.,Hakansson, K.,Liljas, A. (登録日: 1993-04-02, 公開日: 1993-10-31, 最終更新日: 2024-02-14)

主引用文献

Jonsson, B.M.,Hakansson, K.,Liljas, A.
The structure of human carbonic anhydrase II in complex with bromide and azide.
FEBS Lett., 322:186-190, 1993

PubMed Abstract: The three-dimensional structure of human carbonic anhydrase II complexed with azide and with bromide was investigated crystallographically. Both of these non-protonated inhibitors replace the zinc and the 'deep' water, two catalytically important water molecules in the active site of the molecule. Both the azide and the bromide ions bind in a distorted tetrahedral manner 0.4 and 1.1 A from the zinc water position, respectively, but are in close contact (2.0 and 2.6 A, respectively) with the zinc ion.

PubMed: 8482389
DOI: 10.1016/0014-5793(93)81565-H

実験手法

X-RAY DIFFRACTION (1.9 Å)