1RAU
SOLUTION STRUCTURE OF AN UNUSUALLY STABLE RNA TETRAPLEX CONTAINING G-AND U-QUARTET STRUCTURES
Summary for 1RAU
| Entry DOI | 10.2210/pdb1rau/pdb |
| Descriptor | RNA (5'-R(*UP*GP*GP*GP*GP*U)-3') (1 entity in total) |
| Functional Keywords | rna, tetraplex |
| Total number of polymer chains | 4 |
| Total formula weight | 7792.79 |
| Authors | Cheong, C.,Moore, P.B. (deposition date: 1993-07-29, release date: 1994-01-31, Last modification date: 2024-05-22) |
| Primary citation | Cheong, C.,Moore, P.B. Solution structure of an unusually stable RNA tetraplex containing G- and U-quartet structures. Biochemistry, 31:8406-8414, 1992 Cited by PubMed Abstract: A model for the solution structure of an RNA tetraplex, (rUGGGGU)4, has been obtained by two-dimensional NMR spectroscopy and molecular dynamics. The molecule is parallel stranded and Hoogsteen base-paired in 50 mM KCl, and it is so stable that three of its six imino protons have exchange half-lives measured in days at 40 degrees C. The tetraplex is stabilized by base stacking and by the hydrogen bonds in four G quartets and at least one U quartet. This is the first indication of the existence of U-quartet structures of which we are aware. PubMed: 1382577DOI: 10.1021/bi00151a003 PDB entries with the same primary citation |
| Experimental method | SOLUTION NMR |
Structure validation
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