1RAU

SOLUTION STRUCTURE OF AN UNUSUALLY STABLE RNA TETRAPLEX CONTAINING G-AND U-QUARTET STRUCTURES

1RAU の概要

• エントリーDOI: 10.2210/pdb1rau/pdb
• 分子名称: RNA (5'-R(*UP*GP*GP*GP*GP*U)-3') (1 entity in total)
• 機能のキーワード: rna, tetraplex
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 7792.79

構造登録者

Cheong, C.,Moore, P.B. (登録日: 1993-07-29, 公開日: 1994-01-31, 最終更新日: 2024-05-22)

主引用文献

Cheong, C.,Moore, P.B.
Solution structure of an unusually stable RNA tetraplex containing G- and U-quartet structures.
Biochemistry, 31:8406-8414, 1992

PubMed Abstract: A model for the solution structure of an RNA tetraplex, (rUGGGGU)4, has been obtained by two-dimensional NMR spectroscopy and molecular dynamics. The molecule is parallel stranded and Hoogsteen base-paired in 50 mM KCl, and it is so stable that three of its six imino protons have exchange half-lives measured in days at 40 degrees C. The tetraplex is stabilized by base stacking and by the hydrogen bonds in four G quartets and at least one U quartet. This is the first indication of the existence of U-quartet structures of which we are aware.

PubMed: 1382577
DOI: 10.1021/bi00151a003

実験手法

SOLUTION NMR