1R46

Structure of human alpha-galactosidase

1R46 の概要

• エントリーDOI: 10.2210/pdb1r46/pdb
• 関連するPDBエントリー: 1R47
• 分子名称: Alpha-galactosidase A, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
• 機能のキーワード: glycoprotein, carbohydrate-binding protein, glycosidase, lysosomal enzyme, (beta/alpha)8 barrel, hydrolase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 94823.84

構造登録者

Garman, S.C.,Garboczi, D.N. (登録日: 2003-10-03, 公開日: 2004-03-16, 最終更新日: 2023-08-23)

• 主引用文献: Garman, S.C.,Garboczi, D.N.; The molecular defect leading to Fabry disease: structure of human alpha-galactosidase; J.Mol.Biol., 337:319-335, 2004; PubMed: 15003450; DOI: 10.1016/j.jmb.2004.01.035

実験手法

X-RAY DIFFRACTION (3.25 Å)