1QTQ

GLUTAMINYL-TRNA SYNTHETASE COMPLEXED WITH TRNA AND AN AMINO ACID ANALOG

1QTQ の概要

• エントリーDOI: 10.2210/pdb1qtq/pdb
• 分子名称: RNA (TRNA GLN II ), PROTEIN (GLUTAMINYL-TRNA SYNTHETASE), SULFATE ION, ... (5 entities in total)
• 機能のキーワード: trna synthetase, glutamine, trnagln, e. coli, complex, ligase-rna complex, ligase/rna
• 由来する生物種: Escherichia coli; 詳細
• 細胞内の位置: Cytoplasm: P00962
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 88353.63

構造登録者

Rath, V.L.,Silvian, L.F.,Beijer, B.,Sproat, B.S.,Steitz, T.A. (登録日: 1998-01-28, 公開日: 1998-05-27, 最終更新日: 2023-08-02)

主引用文献

Rath, V.L.,Silvian, L.F.,Beijer, B.,Sproat, B.S.,Steitz, T.A.
How glutaminyl-tRNA synthetase selects glutamine.
Structure, 6:439-449, 1998

PubMed Abstract: Aminoacyl-tRNA synthetases covalently link a specific amino acid to the correct tRNA. The fidelity of this reaction is essential for accurate protein synthesis. Each synthetase has a specific molecular mechanism to distinguish the correct pair of substrates from the pool of amino acids and isologous tRNA molecules. In the case of glutaminyl-tRNA synthetase (GlnRS) the prior binding of tRNA is required for activation of glutamine by ATP. A complete understanding of amino acid specificity in GlnRS requires the determination of the structure of the synthetase with both tRNA and substrates bound.

PubMed: 9562563
DOI: 10.1016/S0969-2126(98)00046-X

実験手法

X-RAY DIFFRACTION (2.25 Å)