1QOU

CEN (Centroradialis) protein from Antirrhinum

1QOU の概要

• エントリーDOI: 10.2210/pdb1qou/pdb
• 分子名称: CEN (2 entities in total)
• 機能のキーワード: plant protein, influorescence determination in flowering plant meristem, signalling, member of the phosphatidylethanolamine binding protein family
• 由来する生物種: ANTIRRHINUM MAJUS (GARDEN SNAPDRAGON)
• 細胞内の位置: Cytoplasm: Q41261
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 40700.56

構造登録者

Banfield, M.J.,Brady, R.L. (登録日: 1999-11-17, 公開日: 2000-03-31, 最終更新日: 2024-11-20)

主引用文献

Banfield, M.J.,Brady, R.L.
The Structure of Antirrhinum Centroradialis Protein (Cen) Suggests a Role as a Kinase Regulator
J.Mol.Biol., 297:1161-, 2000

PubMed Abstract: Expression of the plant protein centroradialis (CEN) leads to a morphological switch between shoot growth and the development of flower structures (inflorescence). We have determined the crystal structure of Antirrhinum CEN to 1.9 A resolution. This structure confirms the CEN proteins as a subset of the family of phosphatidylethanolamine-binding proteins (PEBP), as predicted from sequence homology. Mammalian forms of PEBP have been found to act as inhibitors of MAP kinase signalling, a central signalling cascade regulating cell differentiation. CEN and PEBP proteins share a similar topology dominated by a large central beta-sheet. The strong conservation of a binding pocket at one end of this sheet which is capable of binding phosphoryl ligands, suggests the biological effects of CEN, like PEBP, arise from the ability of this region to form complexes with phosphorylated ligands, hence interfering with kinases and their effectors.

PubMed: 10764580
DOI: 10.1006/JMBI.2000.3619

実験手法

X-RAY DIFFRACTION (1.9 Å)