1QO6

Solution structure of a pair of modules from the gelatin-binding domain of fibronectin

1QO6 の概要

• エントリーDOI: 10.2210/pdb1qo6/pdb
• 関連するPDBエントリー: 1FBR 1FNA 1FNF 1FNH 1TTF 1TTG 2FN2
• 分子名称: FIBRONECTIN (1 entity in total)
• 機能のキーワード: cell adhesion protein, fibronectin module pair, gelatin-binding
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Secreted, extracellular space, extracellular matrix: P02751
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 11186.24

構造登録者

Bocquier, A.A.,Potts, J.R.,Pickford, A.R.,Campbell, I.D. (登録日: 1999-11-04, 公開日: 2000-01-11, 最終更新日: 2018-01-17)

主引用文献

Bocquier, A.A.,Potts, J.R.,Pickford, A.R.,Campbell, I.D.
Solution Structure of a Pair of Modules from the Gelatin-Binding Domain of Fibronectin
Structure, 7:1451-, 1999

PubMed Abstract: Fibronectin has a role in vital physiological processes such as cell migration during embryogenesis and wound healing. It mediates the attachment of cells to extracellular matrices that contain fibrous collagens. The affinity of fibronectin for native collagen and denatured collagen (gelatin) is located within a 42 kDa domain that contains four type 1 (F1) and two type 2 (F2) modules. A putative ligand-binding site has been located on an isolated F2 module, but the accessibility of this site in the intact domain is unknown. Thus, structural studies of module pairs and larger fragments are required for a better understanding of the interaction between fibronectin and collagen.

PubMed: 10647176
DOI: 10.1016/S0969-2126(00)88336-7

実験手法

SOLUTION NMR