1QMV

thioredoxin peroxidase B from red blood cells

1QMV の概要

• エントリーDOI: 10.2210/pdb1qmv/pdb
• 分子名称: PEROXIREDOXIN-2 (2 entities in total)
• 機能のキーワード: sulphinic acid, thioredoxin, oxidoreductase
• 由来する生物種: HOMO SAPIENS (HUMAN)
• タンパク質・核酸の鎖数: 10
• 化学式量合計: 218627.15

構造登録者

Isupov, M.N.,Littlechild, J.A.,Lebedev, A.A.,Errington, N.,Vagin, A.A.,Schroder, E. (登録日: 1999-10-07, 公開日: 2000-07-28, 最終更新日: 2024-10-23)

主引用文献

Schroder, E.,Littlechild, J.A.,Lebedev, A.A.,Errington, N.,Vagin, A.A.,Isupov, M.N.
Crystal Structure of Decameric 2-Cys Peroxiredoxin from Human Erythrocytes at 1.7 A Resolution.
Structure, 8:605-, 2000

PubMed Abstract: The peroxiredoxins (Prxs) are an emerging family of multifunctional enzymes that exhibit peroxidase activity in vitro, and in vivo participate in a range of cellular processes known to be sensitive to reactive oxygen species. Thioredoxin peroxidase B (TPx-B), a 2-Cys type II Prx from erythrocytes, promotes potassium efflux and down-regulates apoptosis and the recruitment of monocytes by endothelial tissue.

PubMed: 10873855
DOI: 10.1016/S0969-2126(00)00147-7

実験手法

X-RAY DIFFRACTION (1.7 Å)