1QLS

S100C (S100A11),OR CALGIZZARIN, IN COMPLEX WITH ANNEXIN I N-TERMINUS

1QLS の概要

• エントリーDOI: 10.2210/pdb1qls/pdb
• 関連するPDBエントリー: 1A4P 1BO9 1BT6
• 分子名称: S100C PROTEIN, ANNEXIN I, CALCIUM ION, ... (4 entities in total)
• 機能のキーワード: metal-binding protein/inhibitor, s100 family, ef-hand protein, complex (ligand-annexin), ligand of annexin ii, calcium/phospholipid binding protein, metal-binding protein-inhibitor complex
• 由来する生物種: SUS SCROFA (PIG); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 12553.53

構造登録者

Rety, S.,Sopkova, J.,Renouard, M.,Osterloh, D.,Gerke, V.,Russo-Marie, F.,Lewit-Bentley, A. (登録日: 1999-09-15, 公開日: 2000-02-25, 最終更新日: 2024-10-23)

主引用文献

Rety, S.,Osterloh, D.,Arie, J.P.,Tabaries, S.,Seeman, J.,Russo-Marie, F.,Gerke, V.,Lewit-Bentley, A.
Structural Basis of the Ca2+ Dependent Association between S100C (S100A11) and its Target, the N-Terminal Part of Annexin I
Structure, 8:175-, 2000

PubMed Abstract: S100C (S100A11) is a member of the S100 calcium-binding protein family, the function of which is not yet entirely clear, but may include cytoskeleton assembly and dynamics. S100 proteins consist of two EF-hand calcium-binding motifs, connected by a flexible loop. Like several other members of the family, S100C forms a homodimer. A number of S100 proteins form complexes with annexins, another family of calcium-binding proteins that also bind to phospholipids. Structural studies have been undertaken to understand the basis of these interactions.

PubMed: 10673436
DOI: 10.1016/S0969-2126(00)00093-9

実験手法

X-RAY DIFFRACTION (2.3 Å)