1QHV

HUMAN ADENOVIRUS SEROTYPE 2 FIBRE HEAD

1QHV の概要

• エントリーDOI: 10.2210/pdb1qhv/pdb
• 分子名称: PROTEIN (ADENOVIRUS FIBRE), SULFATE ION (3 entities in total)
• 機能のキーワード: receptor binding, extra-ordinary stability, viral protein
• 由来する生物種: Human adenovirus 2
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 21671.02

構造登録者

Van Raaij, M.J.,Louis, N.,Chroboczek, J.,Cusack, S. (登録日: 1999-05-28, 公開日: 1999-09-29, 最終更新日: 2023-08-16)

主引用文献

van Raaij, M.J.,Louis, N.,Chroboczek, J.,Cusack, S.
Structure of the human adenovirus serotype 2 fiber head domain at 1.5 A resolution.
Virology, 262:333-343, 1999

PubMed Abstract: Adenovirus binds to its receptor via the head domain of its fiber protein. We have crystallized the adenovirus serotype 2 (subgroup C) receptor binding domain and solved the structure at 1.5 A resolution by the molecular replacement technique using the known adenovirus type 5 head structure. Included in the high-resolution model are 306 water molecules, five alternative side chain conformations, and individual anisotropic temperature factors for each atom. The overall structure of the serotype 2 head is very similar to its serotype 5 homologue, apart from differences in some of the flexible loops. All but subgroup B adenoviruses are believed to use the recently identified protein CAR (Coxsackievirus and adenovirus receptor) as receptor. By comparison of the two structures and sequence alignment of CAR binding and non-CAR binding serotype fiber heads, we discuss possible receptor binding sites and propose a receptor binding site in a crevice between two monomers on the side of the trimer. The structural basis of the extraordinary stability of the fiber head trimer is also discussed.

PubMed: 10502512
DOI: 10.1006/viro.1999.9849

実験手法

X-RAY DIFFRACTION (1.51 Å)