1QHC

CRYSTAL STRUCTURE OF RIBONUCLEASE A IN COMPLEX WITH 5'-PHOSPHO-2'-DEOXYURIDINE-3'-PYROPHOSPHATE ADENOSINE-3'-PHOSPHATE

1QHC の概要

• エントリーDOI: 10.2210/pdb1qhc/pdb
• 関連するPDBエントリー: 1AFK 1AFL 1AFU
• 分子名称: PROTEIN (RIBONUCLEASE A), ADENYLATE-3'-PHOSPHATE-[[2'-DEOXY-URIDINE-5'-PHOSPHATE]-3'-PHOSPHATE] (3 entities in total)
• 機能のキーワード: hydrolase, ribonuclease, endonuclease, nucleotide inhibitor
• 由来する生物種: Bos taurus (cattle)
• 細胞内の位置: Secreted: P61823
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 29011.35

構造登録者

Leonidas, D.D.,Acharya, K.R. (登録日: 1999-05-12, 公開日: 1999-08-31, 最終更新日: 2023-08-16)

• 主引用文献: Leonidas, D.D.,Shapiro, R.,Irons, L.I.,Russo, N.,Acharya, K.R.; Toward rational design of ribonuclease inhibitors: high-resolution crystal structure of a ribonuclease A complex with a potent 3',5'-pyrophosphate-linked dinucleotide inhibitor.; Biochemistry, 38:10287-10297, 1999; PubMed: 10441122; DOI: 10.1021/bi990900w

実験手法

X-RAY DIFFRACTION (1.7 Å)