1QFV

HISTAMINE BINDING PROTEIN FROM FEMALE BROWN EAR RHIPICEPHALUS APPENDICULATUS

1QFV の概要

• エントリーDOI: 10.2210/pdb1qfv/pdb
• 分子名称: PROTEIN (FEMALE-SPECIFIC HISTAMINE BINDING PROTEIN 2), HISTAMINE (3 entities in total)
• 機能のキーワード: lipocalin, ligand binding protein
• 由来する生物種: Rhipicephalus appendiculatus
• 細胞内の位置: Secreted: O77421
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 39843.17

構造登録者

Paesen, G.C.,Adams, P.L.,Harlos, K.,Nuttal, P.A.,Stuart, D.I. (登録日: 1999-04-14, 公開日: 2000-04-19, 最終更新日: 2024-11-13)

主引用文献

Paesen, G.C.,Adams, P.L.,Harlos, K.,Nuttall, P.A.,Stuart, D.I.
Tick histamine-binding proteins: isolation, cloning, and three-dimensional structure.
Mol.Cell, 3:661-671, 1999

PubMed Abstract: High-affinity histamine-binding proteins (HBPs) were discovered in the saliva of Rhipicephalus appendiculatus ticks. Their ability to outcompete histamine receptors indicates that they suppress inflammation during blood feeding. The crystal structure of a histamine-bound HBP, determined at 1.25 A resolution, reveals a lipocalin fold novel in containing two binding sites for the same ligand. The sites are orthogonally arranged and highly rigid and form an internal surface of unusual polar character that complements the physicochemical properties of histamine. As soluble receptors of histamine, HBPs offer a new strategy for controlling histamine-based diseases.

PubMed: 10360182
DOI: 10.1016/S1097-2765(00)80359-7

実験手法

X-RAY DIFFRACTION (1.36 Å)