1QFU

INFLUENZA VIRUS HEMAGGLUTININ COMPLEXED WITH A NEUTRALIZING ANTIBODY

1QFU の概要

• エントリーDOI: 10.2210/pdb1qfu/pdb
• 分子名称: PROTEIN (HEMAGGLUTININ (HA1 CHAIN)), PROTEIN (HEMAGGLUTININ (HA2 CHAIN)), PROTEIN (IMMUNOGLOBULIN IGG1-KAPPA ANTIBODY (LIGHT CHAIN)), ... (8 entities in total)
• 機能のキーワード: complex (hemagglutinin-immmunoglobulin), hemagglutinin, immunoglobulin, viral protein-immune system complex, viral protein/immune system
• 由来する生物種: Influenza A virus (A/X-31(H3N2)); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 106359.48

構造登録者

Fleury, D.,Gigant, B.,Bizebard, T.,Daniels, R.S.,Skehel, J.J.,Knossow, M. (登録日: 1999-04-14, 公開日: 1999-04-16, 最終更新日: 2023-12-27)

主引用文献

Fleury, D.,Barrere, B.,Bizebard, T.,Daniels, R.S.,Skehel, J.J.,Knossow, M.
A complex of influenza hemagglutinin with a neutralizing antibody that binds outside the virus receptor binding site.
Nat.Struct.Biol., 6:530-534, 1999

PubMed Abstract: The structure of a complex of influenza hemagglutinin (HA) with a neutralizing antibody shows that the antibody binds to HA at a distance from the virus receptor binding site. Comparison of the properties of this antibody and its Fab with those of an antibody that recognizes an epitope overlapping the receptor binding site leads to two main conclusions. First, inhibition of receptor binding is an important component of neutralization. Second, the efficiency of neutralization by the antibodies ranks in the same order as their avidities for HA, and their large size makes these antibodies highly efficient at neutralization, regardless of the location of their epitope in relation to the virus receptor binding site. These observations provide rationales for the range of antibody specificities that are detected in immune sera and for the distribution of sequence changes on the membrane-distal surface of influenza HAs that occur during 'antigenic drift.'

PubMed: 10360354
DOI: 10.1038/9299

実験手法

X-RAY DIFFRACTION (2.8 Å)