1QF4

DESIGN, SYNTHESIS, AND X-RAY CRYSTAL STRUCTURE OF AN ENZYME BOUND BISUBSTRATE HYBRID INHIBITOR OF ADENYLOSUCCINATE SYNTHETASE

1QF4 の概要

• エントリーDOI: 10.2210/pdb1qf4/pdb
• 分子名称: PROTEIN (ADENYLOSUCCINATE SYNTHETASE), PHOSPHATE ION, MAGNESIUM ION, ... (6 entities in total)
• 機能のキーワード: purine biosynthesis, synthetase, gtp-binding, gtp-hydrolysing enzymes, ligase
• 由来する生物種: Escherichia coli
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 48291.38

構造登録者

Hanessian, S.,Lu, P.-P.,Sanceau, J.-Y.,Chemla, P.,Gohda, K.,Fonne-Pfister, R.,Prade, L.,Cowan-Jacob, S.W. (登録日: 1999-04-06, 公開日: 1999-12-02, 最終更新日: 2023-08-16)

主引用文献

Hanessian, S.,Lu, P.P.,Sanceau, J.Y.,Chemla, P.,Gohda, K.,Fonne-Pfister, R.,Prade, L.,Cowan-Jacob, S.W.
An enzyme-bound bisubstrate hybrid inhibitor of adenylosuccinate synthetase
Angew.Chem.Int.Ed.Engl., 38:3159-3162, 1999

PubMed Abstract: Two relatively weak herbicides, hydantocidin phosphate and hadacidin were linked by a C(3) chain to afford a potent inhibitor (the 2S hybrid is shown) of the enzyme adenylosuccinate synthetase. The crystal structures of the bisubstrate-enzyme complexes were determined.

PubMed: 10556888
DOI: 10.1002/(SICI)1521-3773(19991102)38:21<3159::AID-ANIE3159>3.0.CO;2-2

実験手法

X-RAY DIFFRACTION (2.2 Å)