1QDE

CRYSTAL STRUCTURE OF THE ATPASE DOMAIN OF TRANSLATION INITIATION FACTOR 4A FROM SACCHAROMYCES CEREVISIAE-THE PROTOTYPE OF THE DEAD BOX PROTEIN FAMILY

Summary for 1QDE

• Entry DOI: 10.2210/pdb1qde/pdb
• Descriptor: TRANSLATION INITIATION FACTOR 4A, SULFATE ION (3 entities in total)
• Functional Keywords: translation initiation, saccharomyces cerevisiae, dead box protein family, gene regulation
• Biological source: Saccharomyces cerevisiae (baker's yeast)
• Cellular location: Cytoplasm: P10081
• Total number of polymer chains: 1
• Total formula weight: 25262.04

Authors

Benz, J.,Trachsel, H.,Baumann, U. (deposition date: 1999-05-20, release date: 2000-05-23, Last modification date: 2024-02-14)

Primary citation

Benz, J.,Trachsel, H.,Baumann, U.
Crystal structure of the ATPase domain of translation initiation factor 4A from Saccharomyces cerevisiae--the prototype of the DEAD box protein family.
Structure Fold.Des., 7:671-679, 1999

PubMed Abstract: Translation initiation factor 4A (elF4A) is the prototype of the DEAD-box family of proteins. DEAD-box proteins are involved in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. Energy from ATP hydrolysis is used to perform RNA unwinding during initiation of mRNA translation. The presence of elF4A is required for the 43S preinitiation complex to bind to and scan the mRNA.

PubMed: 10404596
DOI: 10.1016/S0969-2126(99)80088-4

Experimental method

X-RAY DIFFRACTION (2 Å)