1QDE

CRYSTAL STRUCTURE OF THE ATPASE DOMAIN OF TRANSLATION INITIATION FACTOR 4A FROM SACCHAROMYCES CEREVISIAE-THE PROTOTYPE OF THE DEAD BOX PROTEIN FAMILY

1QDE の概要

• エントリーDOI: 10.2210/pdb1qde/pdb
• 分子名称: TRANSLATION INITIATION FACTOR 4A, SULFATE ION (3 entities in total)
• 機能のキーワード: translation initiation, saccharomyces cerevisiae, dead box protein family, gene regulation
• 由来する生物種: Saccharomyces cerevisiae (baker's yeast)
• 細胞内の位置: Cytoplasm: P10081
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 25262.04

構造登録者

Benz, J.,Trachsel, H.,Baumann, U. (登録日: 1999-05-20, 公開日: 2000-05-23, 最終更新日: 2024-02-14)

主引用文献

Benz, J.,Trachsel, H.,Baumann, U.
Crystal structure of the ATPase domain of translation initiation factor 4A from Saccharomyces cerevisiae--the prototype of the DEAD box protein family.
Structure Fold.Des., 7:671-679, 1999

PubMed Abstract: Translation initiation factor 4A (elF4A) is the prototype of the DEAD-box family of proteins. DEAD-box proteins are involved in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. Energy from ATP hydrolysis is used to perform RNA unwinding during initiation of mRNA translation. The presence of elF4A is required for the 43S preinitiation complex to bind to and scan the mRNA.

PubMed: 10404596
DOI: 10.1016/S0969-2126(99)80088-4

実験手法

X-RAY DIFFRACTION (2 Å)