1QBV

CRYSTAL STRUCTURE OF THROMBIN COMPLEXED WITH AN GUANIDINE-MIMETIC INHIBITOR

1QBV の概要

• エントリーDOI: 10.2210/pdb1qbv/pdb
• 分子名称: THROMBIN (LIGHT CHAIN), THROMBIN (HEAVY CHAIN), Hirudin, ... (5 entities in total)
• 機能のキーワード: thrombin, inhibitor, 3dp, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Secreted, extracellular space: P00734 P00734; Secreted: P28504
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 35749.75

構造登録者

Bone, R.,Lu, T.,Illig, C.R.,Soll, R.M.,Spurlino, J.C. (登録日: 1999-04-27, 公開日: 1999-10-27, 最終更新日: 2017-10-04)

• 主引用文献: Bone, R.,Lu, T.,Illig, C.R.,Soll, R.M.,Spurlino, J.C.; Structural analysis of thrombin complexed with potent inhibitors incorporating a phenyl group as a peptide mimetic and aminopyridines as guanidine substitutes.; J.Med.Chem., 41:2068-2075, 1998; PubMed: 9622548; DOI: 10.1021/jm970796l

実験手法

X-RAY DIFFRACTION (1.8 Å)