1QBS
HIV-1 PROTEASE INHIBITORS WIIH LOW NANOMOLAR POTENCY
1QBS の概要
エントリーDOI | 10.2210/pdb1qbs/pdb |
分子名称 | HIV-1 PROTEASE, [4-R-(-4-ALPHA,5-ALPHA,6-BETA,7-BETA)]-HEXAHYDRO-5,6-BIS(HYDROXY)-[1,3-BIS([4-HYDROXYMETHYL-PHENYL]METHYL)-4,7-BIS(PHENYLMETHYL)]-2H-1,3-DIAZEPINONE (2 entities in total) |
機能のキーワード | hydrolase (acid proteinase), aspartyl protease |
由来する生物種 | Human immunodeficiency virus 1 |
細胞内の位置 | Gag-Pol polyprotein: Host cell membrane; Lipid-anchor . Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P04585 |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 22114.02 |
構造登録者 | |
主引用文献 | Lam, P.Y.,Ru, Y.,Jadhav, P.K.,Aldrich, P.E.,DeLucca, G.V.,Eyermann, C.J.,Chang, C.H.,Emmett, G.,Holler, E.R.,Daneker, W.F.,Li, L.,Confalone, P.N.,McHugh, R.J.,Han, Q.,Li, R.,Markwalder, J.A.,Seitz, S.P.,Sharpe, T.R.,Bacheler, L.T.,Rayner, M.M.,Klabe, R.M.,Shum, L.,Winslow, D.L.,Kornhauser, D.M.,Jackson, D.A.,Erickson-Viitanen, S.,Hodge, C.N. Cyclic HIV protease inhibitors: synthesis, conformational analysis, P2/P2' structure-activity relationship, and molecular recognition of cyclic ureas. J.Med.Chem., 39:3514-3525, 1996 Cited by PubMed: 8784449DOI: 10.1021/jm9602571 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.8 Å) |
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