1QBS

HIV-1 PROTEASE INHIBITORS WIIH LOW NANOMOLAR POTENCY

1QBS の概要

• エントリーDOI: 10.2210/pdb1qbs/pdb
• 分子名称: HIV-1 PROTEASE, [4-R-(-4-ALPHA,5-ALPHA,6-BETA,7-BETA)]-HEXAHYDRO-5,6-BIS(HYDROXY)-[1,3-BIS([4-HYDROXYMETHYL-PHENYL]METHYL)-4,7-BIS(PHENYLMETHYL)]-2H-1,3-DIAZEPINONE (2 entities in total)
• 機能のキーワード: hydrolase (acid proteinase), aspartyl protease
• 由来する生物種: Human immunodeficiency virus 1
• 細胞内の位置: Gag-Pol polyprotein: Host cell membrane; Lipid-anchor . Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P04585
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22114.02

構造登録者

Ala, P.,Chang, C.-H. (登録日: 1997-04-25, 公開日: 1997-10-15, 最終更新日: 2017-11-29)

• 主引用文献: Lam, P.Y.,Ru, Y.,Jadhav, P.K.,Aldrich, P.E.,DeLucca, G.V.,Eyermann, C.J.,Chang, C.H.,Emmett, G.,Holler, E.R.,Daneker, W.F.,Li, L.,Confalone, P.N.,McHugh, R.J.,Han, Q.,Li, R.,Markwalder, J.A.,Seitz, S.P.,Sharpe, T.R.,Bacheler, L.T.,Rayner, M.M.,Klabe, R.M.,Shum, L.,Winslow, D.L.,Kornhauser, D.M.,Jackson, D.A.,Erickson-Viitanen, S.,Hodge, C.N.; Cyclic HIV protease inhibitors: synthesis, conformational analysis, P2/P2' structure-activity relationship, and molecular recognition of cyclic ureas.; J.Med.Chem., 39:3514-3525, 1996; PubMed: 8784449; DOI: 10.1021/jm9602571

実験手法

X-RAY DIFFRACTION (1.8 Å)