1QBR

HIV-1 PROTEASE INHIBITORS WIIH LOW NANOMOLAR POTENCY

1QBR の概要

• エントリーDOI: 10.2210/pdb1qbr/pdb
• 分子名称: HIV-1 PROTEASE, [4R-(4ALPHA,5ALPHA,6BETA,7BETA)]-3,3'-[[TETRAHYDRO-5,6-DIHYDROXY-2-OXO-4,7-BIS(PHENYLMETHYL)-1H-1,3-DIAZEPINE-1,3(2H)-D IYL] BIS(METHYLENE)]BIS[N-2-THIAZOLYLBENZAMIDE] (2 entities in total)
• 機能のキーワード: hydrolase (acid proteinase), aspartyl protease
• 由来する生物種: Human immunodeficiency virus 1
• 細胞内の位置: Gag-Pol polyprotein: Host cell membrane; Lipid-anchor . Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P04585
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22274.24

構造登録者

Ala, P.,Chang, C.-H. (登録日: 1997-04-25, 公開日: 1997-10-15, 最終更新日: 2024-02-14)

• 主引用文献: Jadhav, P.K.,Ala, P.,Woerner, F.J.,Chang, C.H.,Garber, S.S.,Anton, E.D.,Bacheler, L.T.; Cyclic urea amides: HIV-1 protease inhibitors with low nanomolar potency against both wild type and protease inhibitor resistant mutants of HIV.; J.Med.Chem., 40:181-191, 1997; PubMed: 9003516; DOI: 10.1021/jm960586t

実験手法

X-RAY DIFFRACTION (1.8 Å)