Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

1QBJ

CRYSTAL STRUCTURE OF THE ZALPHA Z-DNA COMPLEX

Summary for 1QBJ
Entry DOI10.2210/pdb1qbj/pdb
DescriptorDNA (5'-D(*TP*CP*GP*CP*GP*CP*G)-3'), PROTEIN (DOUBLE-STRANDED RNA SPECIFIC ADENOSINE DEAMINASE (ADAR1)) (3 entities in total)
Functional Keywordsprotein-z-dna complex, hydrolase-dna complex, hydrolase/dna
Biological sourceHomo sapiens (human)
More
Cellular locationCytoplasm: P55265
Total number of polymer chains6
Total formula weight33350.07
Authors
Schwartz, T.,Rould, M.A.,Rich, A. (deposition date: 1999-04-22, release date: 1999-07-02, Last modification date: 2024-02-14)
Primary citationSchwartz, T.,Rould, M.A.,Lowenhaupt, K.,Herbert, A.,Rich, A.
Crystal structure of the Zalpha domain of the human editing enzyme ADAR1 bound to left-handed Z-DNA.
Science, 284:1841-1845, 1999
Cited by
PubMed Abstract: The editing enzyme double-stranded RNA adenosine deaminase includes a DNA binding domain, Zalpha, which is specific for left-handed Z-DNA. The 2.1 angstrom crystal structure of Zalpha complexed to DNA reveals that the substrate is in the left-handed Z conformation. The contacts between Zalpha and Z-DNA are made primarily with the "zigzag" sugar-phosphate backbone, which provides a basis for the specificity for the Z conformation. A single base contact is observed to guanine in the syn conformation, characteristic of Z-DNA. Intriguingly, the helix-turn-helix motif, frequently used to recognize B-DNA, is used by Zalpha to contact Z-DNA.
PubMed: 10364558
DOI: 10.1126/science.284.5421.1841
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.1 Å)
Structure validation

227111

건을2024-11-06부터공개중

PDB statisticsPDBj update infoContact PDBjnumon