1QA6
CRYSTAL STRUCTURE OF A CONSERVED RIBOSOMAL PROTEIN-RNA COMPLEX
Summary for 1QA6
| Entry DOI | 10.2210/pdb1qa6/pdb |
| Descriptor | 58 NUCLEOTIDE RIBOSOMAL RNA DOMAIN, RIBOSOMAL PROTEIN L11, MAGNESIUM ION, ... (4 entities in total) |
| Functional Keywords | ribosomal rna, tertiary structur, e rna-protein interaction, minor groove binding, antibiotic binding, ribosome |
| Biological source | Geobacillus stearothermophilus More |
| Total number of polymer chains | 4 |
| Total formula weight | 52541.23 |
| Authors | Conn, G.L.,Draper, D.E.,Lattman, E.E.,Gittis, A.G. (deposition date: 1999-04-15, release date: 1999-05-25, Last modification date: 2024-02-14) |
| Primary citation | Conn, G.L.,Draper, D.E.,Lattman, E.E.,Gittis, A.G. Crystal structure of a conserved ribosomal protein-RNA complex. Science, 284:1171-1174, 1999 Cited by PubMed Abstract: The structure of a highly conserved complex between a 58-nucleotide domain of large subunit ribosomal RNA and the RNA-binding domain of ribosomal protein L11 has been solved at 2.8 angstrom resolution. It reveals a precisely folded RNA structure that is stabilized by extensive tertiary contacts and contains an unusually large core of stacked bases. A bulge loop base from one hairpin of the RNA is intercalated into the distorted major groove of another helix; the protein locks this tertiary interaction into place by binding to the intercalated base from the minor groove side. This direct interaction with a key ribosomal RNA tertiary interaction suggests that part of the role of L11 is to stabilize an unusual RNA fold within the ribosome. PubMed: 10325228DOI: 10.1126/science.284.5417.1171 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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