1PRW

Crystal structure of bovine brain Ca++ calmodulin in a compact form

1PRW の概要

• エントリーDOI: 10.2210/pdb1prw/pdb
• 関連するPDBエントリー: 1CDL 1CDM 1CLN
• 分子名称: Calmodulin, CALCIUM ION (3 entities in total)
• 機能のキーワード: ef hand, calcium-binding protein, kinase activator, metal binding protein
• 由来する生物種: Bos taurus (cattle)
• 細胞内の位置: Cytoplasm: P62157
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 16949.78

構造登録者

Fallon, J.L.,Quiocho, F.A. (登録日: 2003-06-20, 公開日: 2003-10-10, 最終更新日: 2025-03-26)

主引用文献

Fallon, J.L.,Quiocho, F.A.
A closed compact structure of native ca(2+)-calmodulin.
Structure, 11:1303-1307, 2003

PubMed Abstract: Calmodulin has been a subject of intense scrutiny since its discovery because of its unusual properties in regulating the functions of about 100 diverse target enzymes and structural proteins. The original and to date only crystal conformation of native eukaryotic Ca(2+)-calmodulin (Ca(2+)-CaM) is a very extended molecule with two widely separated globular domains linked by an exposed long helix. Here we report the 1.7 A X-ray structure of a new native Ca(2+)-CaM that is in a compact ellipsoidal conformation and shows a sharp bend in the linker helix and a more contracted N-terminal domain. This conformation may offer advantages for recognition of kinase-type calmodulin targets or small organic molecule drugs.

PubMed: 14527397
DOI: 10.1016/j.str.2003.09.004

実験手法

X-RAY DIFFRACTION (1.7 Å)