1PCI

PROCARICAIN

1PCI の概要

• エントリーDOI: 10.2210/pdb1pci/pdb
• 分子名称: PROCARICAIN (1 entity in total)
• 機能のキーワード: zymogen, hydrolase, thiol protease
• 由来する生物種: Carica papaya (papaya)
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 107820.98

構造登録者

Groves, M.R.,Taylor, M.A.J.,Scott, M.,Cummings, N.J.,Pickersgill, R.W.,Jenkins, J.A. (登録日: 1996-06-28, 公開日: 1997-04-01, 最終更新日: 2023-08-09)

主引用文献

Groves, M.R.,Taylor, M.A.,Scott, M.,Cummings, N.J.,Pickersgill, R.W.,Jenkins, J.A.
The prosequence of procaricain forms an alpha-helical domain that prevents access to the substrate-binding cleft.
Structure, 4:1193-1203, 1996

PubMed Abstract: Cysteine proteases are involved in a variety of cellular processes including cartilage degradation in arthritis, the progression of Alzheimer's disease and cancer invasion: these enzymes are therefore of immense biological importance. Caricain is the most basic of the cysteine proteases found in the latex of Carica papaya. It is a member of the papain superfamily and is homologous to other plant and animal cysteine proteases. Caricain is naturally expressed as an inactive zymogen called procaricain. The inactive form of the protease contains an inhibitory proregion which consists of an additional 106 N-terminal amino acids; the proregion is removed upon activation.

PubMed: 8939744
DOI: 10.1016/S0969-2126(96)00127-X

実験手法

X-RAY DIFFRACTION (3.2 Å)