1PAX

THE CATALYTIC FRAGMENT OF POLY(ADP-RIBOSE) POLYMERASE COMPLEXED WITH 3,4-DIHYDRO-5-METHYL-ISOQUINOLINONE

1PAX の概要

• エントリーDOI: 10.2210/pdb1pax/pdb
• 分子名称: POLY(ADP-RIBOSE) POLYMERASE, 3,4-DIHYDRO-5-METHYL-ISOQUINOLINONE (3 entities in total)
• 機能のキーワード: transferase, glycosyltransferase, nad(+) adp-ribosyltransferase
• 由来する生物種: Gallus gallus (chicken)
• 細胞内の位置: Nucleus: P26446
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 40576.55

構造登録者

Ruf, A.,Schulz, G.E. (登録日: 1996-05-06, 公開日: 1997-05-15, 最終更新日: 2024-02-14)

主引用文献

Ruf, A.,Mennissier de Murcia, J.,de Murcia, G.,Schulz, G.E.
Structure of the catalytic fragment of poly(ADP-ribose) polymerase from chicken.
Proc.Natl.Acad.Sci.USA, 93:7481-7485, 1996

PubMed Abstract: The crystal structures of the catalytic fragment of chicken poly(ADP-ribose) polymerase [NAD+ ADP-ribosyltransferase; NAD+:poly(adenosine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyltransferase, EC 2.4.2.30] with and without a nicotinamide-analogue inhibitor have been elucidated. Because this enzyme is involved in the regulation of DNA repair, its inhibitors are of interest for cancer therapy. The inhibitor shows the nicotinamide site and also suggests the adenosine site. The enzyme is structurally related to bacterial ADP-ribosylating toxins but contains an additional alpha-helical domain that is suggested to relay the activation signal issued on binding to damaged DNA.

PubMed: 8755499
DOI: 10.1073/pnas.93.15.7481

実験手法

X-RAY DIFFRACTION (2.4 Å)