1P7B

Crystal structure of an inward rectifier potassium channel

1P7B の概要

• エントリーDOI: 10.2210/pdb1p7b/pdb
• 分子名称: integral membrane channel and cytosolic domains, POTASSIUM ION (3 entities in total)
• 機能のキーワード: transmembrane helices, ion conduction, immunoglobulin fold, cytosolic assembly, metal transport
• 由来する生物種: Burkholderia pseudomallei
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 74511.37

構造登録者

Kuo, A.,Gulbis, J.M.,Antcliff, J.F.,Rahman, T.,Lowe, E.D.,Zimmer, J.,Cuthbertson, J.,Ashcroft, F.M.,Ezaki, T.,Doyle, D.A. (登録日: 2003-05-01, 公開日: 2003-06-17, 最終更新日: 2024-02-14)

主引用文献

Kuo, A.,Gulbis, J.M.,Antcliff, J.F.,Rahman, T.,Lowe, E.D.,Zimmer, J.,Cuthbertson, J.,Ashcroft, F.M.,Ezaki, T.,Doyle, D.A.
Crystal structure of the potassium channel KirBac1.1 in the closed state.
Science, 300:1922-1926, 2003

PubMed Abstract: The KirBac1.1 channel belongs to the inward-rectifier family of potassium channels. Here we report the structure of the entire prokaryotic Kir channel assembly, in the closed state, refined to a resolution of 3.65 angstroms. We identify the main activation gate and structural elements involved in gating. On the basis of structural evidence presented here, we suggest that gating involves coupling between the intracellular and membrane domains. This further suggests that initiation of gating by membrane or intracellular signals represents different entry points to a common mechanistic pathway.

PubMed: 12738871
DOI: 10.1126/science.1085028

実験手法

X-RAY DIFFRACTION (3.65 Å)