1P2A

The structure of cyclin dependent kinase 2 (CKD2) with a trisubstituted naphthostyril inhibitor

Summary for 1P2A

Related1FVT
DescriptorCell division protein kinase 2, 5-[(2-AMINOETHYL)AMINO]-6-FLUORO-3-(1H-PYRROL-2-YL)BENZO[CD]INDOL-2(1H)-ONE (3 entities in total)
Functional Keywordscyclin dependent kinase, naphthostyril oxindole, transferase
Biological sourceHomo sapiens (human)
Total number of polymer chains1
Total molecular weight34286.81
Authors
Liu, J.-J.,Dermatakis, A.,Lukacs, C.M.,Konzelmann, F.,Chen, Y.,Kammlott, U.,Depinto, W.,Yang, H.,Yin, X.,Chen, Y.,Schutt, A.,Simcox, M.E.,Luk, K.-C. (deposition date: 2003-04-15, release date: 2003-07-15, Last modification date: 2011-07-13)
Primary citation
Liu, J.-J.,Dermatakis, A.,Lukacs, C.M.,Konzelmann, F.,Chen, Y.,Kammlott, U.,Depinto, W.,Yang, H.,Yin, X.,Chen, Y.,Schutt, A.,Simcox, M.E.,Luk, K.-C.
3,5,6-Trisubstituted Naphthostyrils as CDK2 Inhibitors
BIOORG.MED.CHEM., 13:2465-2468, 2003
PubMed: 12852944 (PDB entries with the same primary citation)
DOI: 10.1016/S0960-894X(03)00488-8
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.5 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliers1504.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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