1P27

Crystal Structure of the Human Y14/Magoh complex

1P27 の概要

• エントリーDOI: 10.2210/pdb1p27/pdb
• 分子名称: Mago nashi protein homolog, RNA-binding protein 8A (3 entities in total)
• 機能のキーワード: rna-binding, nuclear protein, mrna splicing, rna binding protein
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Nucleus: P61326 Q9Y5S9
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 58167.12

構造登録者

Lau, C.K.,Diem, M.D.,Dreyfuss, G.,Van Duyne, G.D. (登録日: 2003-04-14, 公開日: 2003-08-19, 最終更新日: 2024-02-14)

主引用文献

Lau, C.K.,Diem, M.D.,Dreyfuss, G.,Van Duyne, G.D.
Structure of the y14-magoh core of the exon junction complex.
Curr.Biol., 13:933-941, 2003

PubMed Abstract: Splicing of pre-mRNA in eukaryotes imprints the resulting mRNA with a specific multiprotein complex, the exon-exon junction complex (EJC), at the sites of intron removal. The proteins of the EJC, Y14, Magoh, Aly/REF, RNPS1, Srm160, and Upf3, play critical roles in postsplicing processing, including nuclear export and cytoplasmic localization of the mRNA, and the nonsense-mediated mRNA decay (NMD) surveillance process. Y14 and Magoh are of particular interest because they remain associated with the mRNA in the same position after its export to the cytoplasm and require translation of the mRNA for removal. This tenacious, persistent, splicing-dependent, yet RNA sequence-independent, association suggests an important signaling function and must require distinct structural features for these proteins.

PubMed: 12781131
DOI: 10.1016/S0960-9822(03)00328-2

実験手法

X-RAY DIFFRACTION (2 Å)