1OYX

CRYSTAL STRUCTURE OF 3-MBT REPEATS OF LETHAL (3) MALIGNANT BRAIN TUMOR (SELENO-MET) AT 1.85 ANGSTROM

1OYX の概要

• エントリーDOI: 10.2210/pdb1oyx/pdb
• 関連するPDBエントリー: 1OZ2 1OZ3
• 分子名称: Lethal(3)malignant brain tumor-like protein, SULFATE ION, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (4 entities in total)
• 機能のキーワード: propeller, transcription repressor, transcription
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus: Q9Y468
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 116842.82

構造登録者

Wang, W.K.,Tereshko, V.,Boccuni, P.,MacGrogan, D.,Nimer, S.D.,Patel, D.J. (登録日: 2003-04-07, 公開日: 2003-08-19, 最終更新日: 2024-11-13)

主引用文献

Wang, W.K.,Tereshko, V.,Boccuni, P.,MacGrogan, D.,Nimer, S.D.,Patel, D.J.
Malignant brain tumor repeats: a three-leaved propeller architecture with ligand/peptide binding pockets.
Structure, 11:775-789, 2003

PubMed Abstract: We report on the X-ray structure of three 100-amino acid mbt repeats in h-l(3)mbt, a polycomb group protein involved in transcriptional repression, whose gene is located in a region of chromosome 20 associated with hematopoietic malignancies. Interdigitation between the extended arms and cores of the mbt repeats results in a three-leaved propeller-like architecture, containing a central cavity. We have identified one ligand binding pocket per mbt repeat, which accommodates either the morphilino ring of MES or the proline ring of the C-terminal peptide segment, within a cavity lined by aromatic amino acids. Strikingly, phenotypic alterations resulting from point mutations or deletions in the mbt repeats of the related Drosophila SCM protein are clustered in and around the ligand binding pocket.

PubMed: 12842041
DOI: 10.1016/S0969-2126(03)00127-8

実験手法

X-RAY DIFFRACTION (1.85 Å)