1OUN
CRYSTAL STRUCTURE OF NUCLEAR TRANSPORT FACTOR 2 (NTF2)
Summary for 1OUN
| Entry DOI | 10.2210/pdb1oun/pdb |
| Descriptor | NUCLEAR TRANSPORT FACTOR 2 (2 entities in total) |
| Functional Keywords | transport, nuclear transport protein |
| Biological source | Rattus norvegicus (Norway rat) |
| Total number of polymer chains | 2 |
| Total formula weight | 28982.85 |
| Authors | Bullock, T.L.,Stewart, M.J. (deposition date: 1996-02-21, release date: 1997-04-01, Last modification date: 2024-02-14) |
| Primary citation | Bullock, T.L.,Clarkson, W.D.,Kent, H.M.,Stewart, M. The 1.6 angstroms resolution crystal structure of nuclear transport factor 2 (NTF2). J.Mol.Biol., 260:422-431, 1996 Cited by PubMed Abstract: Nuclear transport factor 2 (NTF2) facilitates protein transport into the nucleus and interacts with both the small Ras-like GTPase Ran and nucleoporin p62. We have determined the structure of bacterially expressed rat NTF2 at 1.6 angstroms resolution using X-ray crystallography. The NTF2 polypeptide chain forms an alpha + beta barrel that opens at one end to form a distinctive hydrophobic cavity and its fold is homologous to that of scytalone dehydratase. The NTF2 hydrophobic cavity is a candidate for a potential binding site for other proteins involved in nuclear import such as Ran and nucleoporin p62. In addition, the hydrophobic cavity contains a putative catalytic Asp-His pair, which raises the possibility of an unanticipated enzymatic activity of the molecule that may have implications for the molecular mechanism of nuclear protein import. PubMed: 8757804DOI: 10.1006/jmbi.1996.0411 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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