1OLU

Roles of His291-alpha and His146-beta' in the reductive acylation reaction catalyzed by human branched-chain alpha-ketoacid dehydrogenase

1OLU の概要

• エントリーDOI: 10.2210/pdb1olu/pdb
• 関連するPDBエントリー: 1DTW 1OLS 1OLX
• 分子名称: 2-OXOISOVALERATE DEHYDROGENASE ALPHA SUBUNIT, 2-OXOISOVALERATE DEHYDROGENASE BETA SUBUNIT, POTASSIUM ION, ... (7 entities in total)
• 機能のキーワード: oxidoreductase, ketoacid dehydrogenase, branched-chain, multi-enzyme complex, acylation, oxidative decarboxylation oxidoreductase, maple syrup urine disease, thiamine phosphate
• 由来する生物種: HOMO SAPIENS (HUMAN); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 84302.49

構造登録者

Wynn, R.M.,Machius, M.,Chuang, J.L.,Li, J.,Tomchick, D.R.,Chuang, D.T. (登録日: 2003-08-15, 公開日: 2003-08-28, 最終更新日: 2023-12-13)

• 主引用文献: Wynn, R.M.,Machius, M.,Chuang, J.L.,Li, J.,Tomchick, D.R.,Chuang, D.T.; Roles of His291-Alpha and His146-Beta' in the Reductive Acylation Reaction Catalyzed by Human Branched-Chain Alpha-Ketoacid Dehydrogenase: Refined Phosphorylation Loop Structure in the Active Site.; J.Biol.Chem., 278:43402-, 2003; PubMed: 12902323; DOI: 10.1074/JBC.M306204200

実験手法

X-RAY DIFFRACTION (1.9 Å)