1OLS

Roles of His291-alpha and His146-beta' in the reductive acylation reaction catalyzed by human branched-chain alpha-ketoacid dehydrogenase

Summary for 1OLS

• Entry DOI: 10.2210/pdb1ols/pdb
• Related: 1DTW
• Descriptor: 2-OXOISOVALERATE DEHYDROGENASE ALPHA SUBUNIT, 2-OXOISOVALERATE DEHYDROGENASE BETA SUBUNIT, POTASSIUM ION, ... (7 entities in total)
• Functional Keywords: oxidoreductase, ketoacid dehydrogenase, branched-chain, multi-enzyme complex, acylation, oxidative decarboxylation, maple syrup urine disease, thiamine phosphate
• Biological source: HOMO SAPIENS (HUMAN); More
• Total number of polymer chains: 2
• Total formula weight: 84123.91

Authors

Wynn, R.M.,Machius, M.,Chuang, J.L.,Li, J.,Tomchick, D.R.,Chuang, D.T. (deposition date: 2003-08-12, release date: 2003-08-15, Last modification date: 2023-12-13)

• Primary citation: Wynn, R.M.,Machius, M.,Chuang, J.L.,Li, J.,Tomchick, D.R.,Chuang, D.T.; Roles of His291-Alpha and His146-Beta' in the Reductive Acylation Reaction Catalyzed by Human Branched-Chain Alpha-Ketoacid Dehydrogenase: Refined Phosphorylation Loop Structure in the Active Site.; J.Biol.Chem., 278:43402-, 2003; PubMed: 12902323; DOI: 10.1074/JBC.M306204200

Experimental method

X-RAY DIFFRACTION (1.85 Å)