1OLL

Extracellular region of the human receptor NKp46

1OLL の概要

• エントリーDOI: 10.2210/pdb1oll/pdb
• 分子名称: NK RECEPTOR, 1,2-ETHANEDIOL (3 entities in total)
• 機能のキーワード: immune system/receptor, nk cell triggering receptor, immune system, ig domain, cytotoxicity, c2-type ig-like domains, immune system-receptor complex
• 由来する生物種: HOMO SAPIENS
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 21385.48

構造登録者

Ponassi, M.,Cantoni, C.,Biassoni, R.,Conte, R.,Spallarossa, A.,Pesce, A.,Moretta, A.,Moretta, L.,Bolognesi, M.,Bordo, D. (登録日: 2003-08-07, 公開日: 2003-09-04, 最終更新日: 2024-10-09)

主引用文献

Ponassi, M.,Cantoni, C.,Biassoni, R.,Conte, R.,Spallarossa, A.,Pesce, A.,Moretta, A.,Moretta, L.,Bolognesi, M.,Bordo, D.
Structure of the Human Nk Cell Triggering Receptor Nkp46 Ectodomain
Biochem.Biophys.Res.Commun., 309:317-, 2003

PubMed Abstract: NKp46, a natural killer (NK) cell-specific receptor, has been recently identified as one of the triggering receptors involved in NK cell activation mediated by non-HLA class I ligands. The structure of the NKp46 extracellular receptor region, here reported, consists of two Ig-like domains assembled similarly to leukocyte immunoglobulin-like receptors (LIRs) and killer inhibitory receptors (KIRs). The extensive NKp46 residue substitutions at sites structurally related to those mediating interaction with HLA antigens in LIRs and KIRs indicate that NKp46 recognition processes in vivo should involve non-HLA ligands. NKP46 is shown to stem from an ancestral KIR/LIR family. However, the absence of close paralogues, such as those found for LIR and KIR, indicates that NKp46 is the unique member of a distinct Ig-like subfamily and suggests a specific role, which appears to be maintained across primates and rodents.

PubMed: 12951052
DOI: 10.1016/J.BBRC.2003.08.007

実験手法

X-RAY DIFFRACTION (1.93 Å)