Loading
PDBj
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help

1OLD

NMR STRUCTURE OF 24-MER DEOXYRIBONUCLEIC ACID, 7 STRUCTURES

Summary for 1OLD
Entry DOI10.2210/pdb1old/pdb
DescriptorDNA (GATCGAAACGTAGCGCCTTCGATC), ARGININEAMIDE (2 entities in total)
Functional Keywordsdeoxyribonucleic acid, dna
Total number of polymer chains1
Total formula weight7528.98
Authors
Lin, C.H.,Patel, D.J. (deposition date: 1996-10-31, release date: 1997-04-21, Last modification date: 2024-05-22)
Primary citationLin, C.H.,Patel, D.J.
Encapsulating an amino acid in a DNA fold.
Nat.Struct.Biol., 3:1046-1050, 1996
Cited by
PubMed Abstract: Here we present the first solution structure of a ligand-DNA aptamer complex. Our NMR-molecular dynamics structural studies of the interaction between argininamide and a DNA stem-loop complex establishes that the hairpin loop DNA binding site undergoes an adaptive conformational transition on complex formation. The tip of the DNA loop folds down towards the stem and sandwiches the bound argininamide between reversed Hoogsteen A.C and Watson-Crick G.C base pairs. The argininamide is encapsulated within the structured DNA loop and is stabilized by an intricate set of intermolecular hydrogen bonds and stacking interactions. The structure of the complex lays out the molecular principles defining both the architecture of the internal cavity and the recognition elements that could contribute to ligand discrimination.
PubMed: 8946859
DOI: 10.1038/nsb1296-1046
PDB entries with the same primary citation
Experimental method
SOLUTION NMR
Structure validation

243083

数据于2025-10-15公开中

PDB statisticsPDBj update infoContact PDBjnumon