1OHT

Peptidoglycan recognition protein LB

Summary for 1OHT

• Entry DOI: 10.2210/pdb1oht/pdb
• Descriptor: CG14704 PROTEIN, ZINC ION, 1,2-ETHANEDIOL, ... (5 entities in total)
• Functional Keywords: peptidoglycan-recognition protein-lb isoform 2, hydrolase
• Biological source: DROSOPHILA MELANOGASTER
• Total number of polymer chains: 1
• Total formula weight: 24300.76

Authors

Kim, M.-S.,Byun, M.,Oh, B.-H. (deposition date: 2003-05-31, release date: 2003-07-18, Last modification date: 2011-07-13)

Primary citation

Kim, M.-S.,Byun, M.,Oh, B.-H.
Crystal Structure of Peptidoglycan Recognition Protein Lb from Drosophila Melanogaster
Nat.Immunol., 4:787-, 2003

PubMed Abstract: The family of peptidoglycan recognition proteins (PGRPs) are associated with the recognition of the peptidoglycan of microbes and subsequent activation of signaling pathways for immune response. Here the crystal structure of Drosophila PGRP-LB is determined at a resolution of 2.0 A and shows an active-site cleft with a zinc cage. Poor conservation of surface residues at the cleft predicts a widely varying individual specificity of PGRPs for molecular patterns on microbial cell walls. At the back of this cleft is a putatively conserved distinctive groove. The location and mainly hydrophobic nature of the groove indicate that the back face serves for subsequent signaling after clustering of PGRP molecules by binding to polymeric cell wall components.

PubMed: 12845326
DOI: 10.1038/NI952

Experimental method

X-RAY DIFFRACTION (2 Å)