1OHT

Peptidoglycan recognition protein LB

1OHT の概要

• エントリーDOI: 10.2210/pdb1oht/pdb
• 分子名称: CG14704 PROTEIN, ZINC ION, 1,2-ETHANEDIOL, ... (5 entities in total)
• 機能のキーワード: peptidoglycan-recognition protein-lb isoform 2, hydrolase
• 由来する生物種: DROSOPHILA MELANOGASTER
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 24300.76

構造登録者

Kim, M.-S.,Byun, M.,Oh, B.-H. (登録日: 2003-05-31, 公開日: 2003-07-18, 最終更新日: 2024-11-13)

主引用文献

Kim, M.-S.,Byun, M.,Oh, B.-H.
Crystal Structure of Peptidoglycan Recognition Protein Lb from Drosophila Melanogaster
Nat.Immunol., 4:787-, 2003

PubMed Abstract: The family of peptidoglycan recognition proteins (PGRPs) are associated with the recognition of the peptidoglycan of microbes and subsequent activation of signaling pathways for immune response. Here the crystal structure of Drosophila PGRP-LB is determined at a resolution of 2.0 A and shows an active-site cleft with a zinc cage. Poor conservation of surface residues at the cleft predicts a widely varying individual specificity of PGRPs for molecular patterns on microbial cell walls. At the back of this cleft is a putatively conserved distinctive groove. The location and mainly hydrophobic nature of the groove indicate that the back face serves for subsequent signaling after clustering of PGRP molecules by binding to polymeric cell wall components.

PubMed: 12845326
DOI: 10.1038/NI952

実験手法

X-RAY DIFFRACTION (2 Å)