1O2G

Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors

Summary for 1O2G

• Entry DOI: 10.2210/pdb1o2g/pdb
• Related: 1C5N
• Descriptor: THROMBIN, ACETYL HIRUDIN, SODIUM ION, ... (6 entities in total)
• Functional Keywords: serine protease, short hydrogen bond, inhibition mechanism, shift of pka, trypsin, thrombin, urokinase, factor xa, blood clotting, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase-inhibitor complex, hydrolase/inhibitor
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted, extracellular space: P00734 P00734; Secreted: P28504
• Total number of polymer chains: 3
• Total formula weight: 35718.65

Authors

Katz, B.A.,Elrod, K.,Verner, E.,Mackman, R.L.,Luong, C.,Shrader, W.,Sendzik, M.,Spencer, J.R.,Sprengeler, P.A.,Kolesnikov, A.,Tai, W.F.,Hui, H.,Breitenbucher, G.,Allen, D.,Janc, J. (deposition date: 2003-03-06, release date: 2003-05-13, Last modification date: 2023-11-15)

• Primary citation: Katz, B.A.,Elrod, K.,Verner, E.,Mackman, R.L.,Luong, C.,Shrader, W.D.,Sendzik, M.,Spencer, J.R.,Sprengeler, P.A.,Kolesnikov, A.,Tai, V.W.-F.,Hui, H.C.,Breitenbucher, J.G.,Allen, D.,Janc, J.W.; Elaborate Manifold of Short Hydrogen Bond Arrays Mediating Binding of Active Site-Directed Serine Protease Inhibitors; J.Mol.Biol., 329:93-120, 2003; PubMed: 12742021; DOI: 10.1016/S0022-2836(03)00399-1

Experimental method

X-RAY DIFFRACTION (1.58 Å)