1NYG

NMR STUDY OF THE SH3 DOMAIN FROM FYN PROTO-ONCOGENE TYROSINE KINASE, FAMILY OF 20 STRUCTURES

1NYG の概要

• エントリーDOI: 10.2210/pdb1nyg/pdb
• 分子名称: FYN (1 entity in total)
• 機能のキーワード: sh3 domain, polyproline-binding, phosphotransferase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cell membrane: P06241
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 7554.11

構造登録者

Morton, C.J.,Pugh, D.J.R.,Campbell, I.D. (登録日: 1996-04-22, 公開日: 1996-11-08, 最終更新日: 2024-05-22)

主引用文献

Morton, C.J.,Pugh, D.J.,Brown, E.L.,Kahmann, J.D.,Renzoni, D.A.,Campbell, I.D.
Solution structure and peptide binding of the SH3 domain from human Fyn.
Structure, 4:705-714, 1996

PubMed Abstract: The Src family of tyrosine kinases is involved in the propagation of intracellular signals from many transmembrane receptors. Each member of the family contains two domains that regulate interactions with other molecules, one of which is the Src homology 3 (SH3) domain. Although structures have previously been determined for SH3 domains, and ideas about peptide-binding modes have been proposed, their physiological role is still unclear.

PubMed: 8805554
DOI: 10.1016/S0969-2126(96)00076-7

実験手法

SOLUTION NMR