1NYF

NMR STUDY OF THE SH3 DOMAIN FROM FYN PROTO-ONCOGENE TYROSINE KINASE, MINIMIZED AVERAGE (PROBMAP) STRUCTURE

Summary for 1NYF

• Entry DOI: 10.2210/pdb1nyf/pdb
• Descriptor: FYN (1 entity in total)
• Functional Keywords: sh3 domain, polyproline-binding, phosphotransferase
• Biological source: Homo sapiens (human)
• Cellular location: Cell membrane: P06241
• Total number of polymer chains: 1
• Total formula weight: 7554.11

Authors

Morton, C.J.,Pugh, D.J.R.,Campbell, I.D. (deposition date: 1996-04-22, release date: 1996-11-08, Last modification date: 2024-05-22)

Primary citation

Morton, C.J.,Pugh, D.J.,Brown, E.L.,Kahmann, J.D.,Renzoni, D.A.,Campbell, I.D.
Solution structure and peptide binding of the SH3 domain from human Fyn.
Structure, 4:705-714, 1996

PubMed Abstract: The Src family of tyrosine kinases is involved in the propagation of intracellular signals from many transmembrane receptors. Each member of the family contains two domains that regulate interactions with other molecules, one of which is the Src homology 3 (SH3) domain. Although structures have previously been determined for SH3 domains, and ideas about peptide-binding modes have been proposed, their physiological role is still unclear.

PubMed: 8805554
DOI: 10.1016/S0969-2126(96)00076-7

Experimental method

SOLUTION NMR