1NWE
Ptp1B R47C Modified at C47 with N-[4-(2-{2-[3-(2-Bromo-acetylamino)-propionylamino]-3-hydroxy-propionylamino}-ethyl)-phenyl]-oxalamic acid
Summary for 1NWE
Entry DOI | 10.2210/pdb1nwe/pdb |
Descriptor | Protein-tyrosine phosphatase, non-receptor type 1, N-[4-(2-{2-[3-(2-BROMO-ACETYLAMINO)-PROPIONYLAMINO]-3-HYDROXY-PROPIONYLAMINO}-ETHYL)-PHENYL]-OXALAMIC ACID (2 entities in total) |
Functional Keywords | hydrolase, acetylation, phosphorylation, phospatase, phosphotyrosine mimetic |
Biological source | Homo sapiens (human) |
Cellular location | Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side : P18031 |
Total number of polymer chains | 1 |
Total formula weight | 35133.74 |
Authors | Erlanson, D.A.,McDowell, R.S.,He, M.M.,Randal, M.,Simmons, R.L.,Kung, J.,Waight, A.,Hansen, S.K. (deposition date: 2003-02-06, release date: 2003-05-06, Last modification date: 2024-04-03) |
Primary citation | Erlanson, D.A.,McDowell, R.S.,He, M.M.,Randal, M.,Simmons, R.L.,Kung, J.,Waight, A.,Hansen, S.K. Discovery of a New Phosphotyrosine Mimetic for PTP1B Using Breakaway Tethering J.Am.Chem.Soc., 125:5602-5603, 2003 Cited by PubMed: 12733877DOI: 10.1021/ja034440c PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.1 Å) |
Structure validation
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