1NUH

The crystal structure of human phosphoglucose isomerase complexed with 5-phosphoarabinonate

1NUH の概要

• エントリーDOI: 10.2210/pdb1nuh/pdb
• 関連するPDBエントリー: 1IAT
• 分子名称: glucose phosphate isomerase, SULFATE ION, 5-PHOSPHOARABINONIC ACID, ... (4 entities in total)
• 機能のキーワード: aldose-ketose isomerase, glycolysis enzyme, neurotrophic growth factor, cytokine, isomerase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm : P06744
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 64052.44

構造登録者

Davies, C. (登録日: 2003-01-31, 公開日: 2003-02-11, 最終更新日: 2024-12-25)

主引用文献

Davies, C.,Muirhead, H.,Chirgwin, J.
The structure of human phosphoglucose isomerase complexed with a transition-state analogue.
Acta Crystallogr.,Sect.D, 59:1111-1113, 2003

PubMed Abstract: Phosphoglucose isomerase (PGI) is a workhorse enzyme of carbohydrate metabolism that interconverts glucose 6-phosphate and fructose 6-phosphate. Outside the cell, however, the protein appears to function as a cytokine. A crystal structure of human PGI bound with 5-phosphoarabinonate, a strong inhibitor that mimics the cis-enediol(ate) intermediate of the reaction, has been determined at 2.5 A resolution. The structure helps to confirm the assignment of Glu357 as the base catalyst in the isomerase reaction.

PubMed: 12777791
DOI: 10.1107/S0907444903007352

実験手法

X-RAY DIFFRACTION (2.51 Å)