1NRL

Crystal Structure of the human PXR-LBD in complex with an SRC-1 coactivator peptide and SR12813

Summary for 1NRL

• Entry DOI: 10.2210/pdb1nrl/pdb
• Related: 1ILG 1ILH 1M13
• Descriptor: Orphan nuclear receptor PXR, Nuclear Receptor Coactivator 1 isoform 3, [2-(3,5-DI-TERT-BUTYL-4-HYDROXY-PHENYL)-1-(DIETHOXY-PHOSPHORYL)-VINYL]-PHOSPHONIC ACID DIETHLYL ESTER, ... (4 entities in total)
• Functional Keywords: nuclear receptor, coactivator, pxr, xenobiotic, src-1, ligand binding domain, transcription
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus: O75469
• Total number of polymer chains: 4
• Total formula weight: 79183.13

Authors

Watkins, R.E.,Davis-Searles, P.R.,Lambert, M.H.,Redinbo, M.R. (deposition date: 2003-01-25, release date: 2003-08-19, Last modification date: 2024-02-14)

• Primary citation: Watkins, R.E.,Davis-Searles, P.R.,Lambert, M.H.,Redinbo, M.R.; Coactivator binding promotes the specific interaction between ligand and the pregnane X receptor; J.Mol.Biol., 331:815-828, 2003; PubMed: 12909012; DOI: 10.1016/S0022-2836(03)00795-2

Experimental method

X-RAY DIFFRACTION (2 Å)