1NRL
Crystal Structure of the human PXR-LBD in complex with an SRC-1 coactivator peptide and SR12813
Summary for 1NRL
Entry DOI | 10.2210/pdb1nrl/pdb |
Related | 1ILG 1ILH 1M13 |
Descriptor | Orphan nuclear receptor PXR, Nuclear Receptor Coactivator 1 isoform 3, [2-(3,5-DI-TERT-BUTYL-4-HYDROXY-PHENYL)-1-(DIETHOXY-PHOSPHORYL)-VINYL]-PHOSPHONIC ACID DIETHLYL ESTER, ... (4 entities in total) |
Functional Keywords | nuclear receptor, coactivator, pxr, xenobiotic, src-1, ligand binding domain, transcription |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus: O75469 |
Total number of polymer chains | 4 |
Total formula weight | 79183.13 |
Authors | Watkins, R.E.,Davis-Searles, P.R.,Lambert, M.H.,Redinbo, M.R. (deposition date: 2003-01-25, release date: 2003-08-19, Last modification date: 2024-02-14) |
Primary citation | Watkins, R.E.,Davis-Searles, P.R.,Lambert, M.H.,Redinbo, M.R. Coactivator binding promotes the specific interaction between ligand and the pregnane X receptor J.Mol.Biol., 331:815-828, 2003 Cited by PubMed: 12909012DOI: 10.1016/S0022-2836(03)00795-2 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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