1NQ3

Crystal structure of the mammalian tumor associated antigen UK114

Summary for 1NQ3

• Entry DOI: 10.2210/pdb1nq3/pdb
• Related: 1J7H 1JD1 1QD9 1QU9
• Descriptor: 14.3 kDa perchloric acid soluble protein (2 entities in total)
• Functional Keywords: tumor associated antigen, yer057c/yil051c/yjgf protein family, uk114, trimer, immune system, metal binding protein
• Biological source: Capra hircus (goat)
• Cellular location: Cell surface: P80601
• Total number of polymer chains: 6
• Total formula weight: 85068.95

Authors

Deriu, D.,Briand, C.,Mistiniene, E.,Naktinis, V.,Grutter, M.G. (deposition date: 2003-01-21, release date: 2003-08-26, Last modification date: 2023-08-16)

Primary citation

Deriu, D.,Briand, C.,Mistiniene, E.,Naktinis, V.,Grutter, M.G.
Structure and oligomeric state of the mammalian tumour-associated antigen UK114.
Acta Crystallogr.,Sect.D, 59:1676-1678, 2003

PubMed Abstract: The tumour-associated antigen UK114, isolated from goat liver, belongs to the YER057c/YIL051c/YjgF protein family, which has members in both the prokaryotes and eukaryotes. The crystal structure of a mammalian representative, goat UK114, was determined, revealing a trimeric arrangement in the crystal. It was confirmed by ultracentrifugation that UK114 is a trimer in solution. These results are in agreement with the published structures of homologues from unicellular organisms, but contrast with those reported for the rat homologue of UK114, for which a dimeric quaternary structure was proposed.

PubMed: 12925811
DOI: 10.1107/S0907444903014306

Experimental method

X-RAY DIFFRACTION (2.2 Å)