1NQ3

Crystal structure of the mammalian tumor associated antigen UK114

1NQ3 の概要

• エントリーDOI: 10.2210/pdb1nq3/pdb
• 関連するPDBエントリー: 1J7H 1JD1 1QD9 1QU9
• 分子名称: 14.3 kDa perchloric acid soluble protein (2 entities in total)
• 機能のキーワード: tumor associated antigen, yer057c/yil051c/yjgf protein family, uk114, trimer, immune system, metal binding protein
• 由来する生物種: Capra hircus (goat)
• 細胞内の位置: Cell surface: P80601
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 85068.95

構造登録者

Deriu, D.,Briand, C.,Mistiniene, E.,Naktinis, V.,Grutter, M.G. (登録日: 2003-01-21, 公開日: 2003-08-26, 最終更新日: 2023-08-16)

主引用文献

Deriu, D.,Briand, C.,Mistiniene, E.,Naktinis, V.,Grutter, M.G.
Structure and oligomeric state of the mammalian tumour-associated antigen UK114.
Acta Crystallogr.,Sect.D, 59:1676-1678, 2003

PubMed Abstract: The tumour-associated antigen UK114, isolated from goat liver, belongs to the YER057c/YIL051c/YjgF protein family, which has members in both the prokaryotes and eukaryotes. The crystal structure of a mammalian representative, goat UK114, was determined, revealing a trimeric arrangement in the crystal. It was confirmed by ultracentrifugation that UK114 is a trimer in solution. These results are in agreement with the published structures of homologues from unicellular organisms, but contrast with those reported for the rat homologue of UK114, for which a dimeric quaternary structure was proposed.

PubMed: 12925811
DOI: 10.1107/S0907444903014306

実験手法

X-RAY DIFFRACTION (2.2 Å)