1NPV

Crystal structure of HIV-1 protease complexed with LDC271

Summary for 1NPV

• Entry DOI: 10.2210/pdb1npv/pdb
• Descriptor: POL polyprotein, {1-BENZYL-3-[2-BENZYL-3-OXO-4-(1-OXO-1,2,3,4-TETRAHYDRO- ISOQUINOLIN-4-YL)-2,3-DIHYDRO-1H-PYRROL-2-YL]-2- HYDROXY-PROPYL}-CARBAMIC ACID TETRAHYDRO-FURAN-3-YL ESTER (3 entities in total)
• Functional Keywords: protease, hydrolase
• Biological source: Human immunodeficiency virus 1
• Total number of polymer chains: 2
• Total formula weight: 22203.20

Authors

Smith, A.B. (deposition date: 2003-01-20, release date: 2003-02-04, Last modification date: 2024-02-14)

• Primary citation: Smith, A.B.,Cantin, L.D.,Pasternak, A.,Guise-Zawacki, L.,Yao, W.,Charnley, A.K.,Barbosa, J.,Sprengeler, P.A.,Hirschmann, R.,Munshi, S.,Olsen, D.B.,Schleif, W.A.,Kuo, L.C.; Design, synthesis, and biological evaluation of monopyrrolinone-based HIV-1 protease inhibitors.; J.Med.Chem., 46:1831-1844, 2003; PubMed: 12723947; DOI: 10.1021/jm0204587

Experimental method

X-RAY DIFFRACTION (2 Å)