1NP4

CRYSTAL STRUCTURE OF NITROPHORIN 4 FROM RHODNIUS PROLIXUS

Summary for 1NP4

• Entry DOI: 10.2210/pdb1np4/pdb
• Descriptor: PROTEIN (NITROPHORIN 4), PROTOPORPHYRIN IX CONTAINING FE, AMMONIA, ... (4 entities in total)
• Functional Keywords: nitric oxide transport, ferric heme, antihistamine, vasodilator, lipocalin, bilin binding protein, transport protein
• Biological source: Rhodnius prolixus
• Cellular location: Secreted: Q94734
• Total number of polymer chains: 1
• Total formula weight: 20926.18

Authors

Andersen, J.F.,Weichsel, A.,Champagne, D.E.,Balfour, C.A.,Montfort, W.R. (deposition date: 1998-07-29, release date: 1998-08-05, Last modification date: 2024-11-20)

Primary citation

Andersen, J.F.,Weichsel, A.,Balfour, C.A.,Champagne, D.E.,Montfort, W.R.
The crystal structure of nitrophorin 4 at 1.5 A resolution: transport of nitric oxide by a lipocalin-based heme protein.
Structure, 6:1315-1327, 1998

PubMed Abstract: Nitrophorins are nitric oxide (NO) transport proteins from the saliva of blood-feeding insects, which act as vasodilators and anti-platelet agents. Rhodnius prolixus, an insect that carries the trypanosome that causes Chagas' disease, releases four NO-loaded nitrophorins during blood feeding, whereupon the ligand is released into the bloodstream or surrounding tissue of the host. Histamine, a signaling molecule released by the host upon tissue damage, is tightly bound by the nitrophorins; this may facilitate the release of NO and reduce inflammation in the host.

PubMed: 9782054
DOI: 10.1016/S0969-2126(98)00131-2

Experimental method

X-RAY DIFFRACTION (1.5 Å)