1NP4

CRYSTAL STRUCTURE OF NITROPHORIN 4 FROM RHODNIUS PROLIXUS

1NP4 の概要

• エントリーDOI: 10.2210/pdb1np4/pdb
• 分子名称: PROTEIN (NITROPHORIN 4), PROTOPORPHYRIN IX CONTAINING FE, AMMONIA, ... (4 entities in total)
• 機能のキーワード: nitric oxide transport, ferric heme, antihistamine, vasodilator, lipocalin, bilin binding protein, transport protein
• 由来する生物種: Rhodnius prolixus
• 細胞内の位置: Secreted: Q94734
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 20926.18

構造登録者

Andersen, J.F.,Weichsel, A.,Champagne, D.E.,Balfour, C.A.,Montfort, W.R. (登録日: 1998-07-29, 公開日: 1998-08-05, 最終更新日: 2024-11-20)

主引用文献

Andersen, J.F.,Weichsel, A.,Balfour, C.A.,Champagne, D.E.,Montfort, W.R.
The crystal structure of nitrophorin 4 at 1.5 A resolution: transport of nitric oxide by a lipocalin-based heme protein.
Structure, 6:1315-1327, 1998

PubMed Abstract: Nitrophorins are nitric oxide (NO) transport proteins from the saliva of blood-feeding insects, which act as vasodilators and anti-platelet agents. Rhodnius prolixus, an insect that carries the trypanosome that causes Chagas' disease, releases four NO-loaded nitrophorins during blood feeding, whereupon the ligand is released into the bloodstream or surrounding tissue of the host. Histamine, a signaling molecule released by the host upon tissue damage, is tightly bound by the nitrophorins; this may facilitate the release of NO and reduce inflammation in the host.

PubMed: 9782054
DOI: 10.1016/S0969-2126(98)00131-2

実験手法

X-RAY DIFFRACTION (1.5 Å)