1NOX
NADH OXIDASE FROM THERMUS THERMOPHILUS
Summary for 1NOX
| Entry DOI | 10.2210/pdb1nox/pdb |
| Descriptor | NADH OXIDASE, FLAVIN MONONUCLEOTIDE (3 entities in total) |
| Functional Keywords | flavoenzyme, flavoprotein fmn, oxidoreductase, thermophile |
| Biological source | Thermus thermophilus |
| Total number of polymer chains | 1 |
| Total formula weight | 23236.80 |
| Authors | Hecht, H.J.,Erdmann, H.,Park, H.J.,Sprinzl, M.,Schmid, R.D. (deposition date: 1996-11-20, release date: 1997-03-12, Last modification date: 2024-04-03) |
| Primary citation | Hecht, H.J.,Erdmann, H.,Park, H.J.,Sprinzl, M.,Schmid, R.D. Crystal structure of NADH oxidase from Thermus thermophilus. Nat.Struct.Biol., 2:1109-1114, 1995 Cited by PubMed Abstract: The crystal structures of the flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN) containing isoforms of NADH oxidase from Thermus thermophilus have been determined by isomorphous and molecular replacement and refined to 2.3 A and 1.6 A resolution with R-values of 18.5% and 18.6% respectively. The structure of the homodimeric enzyme consists of a central 4-stranded antiparallel beta-sheet covered by helices, a more flexible domain formed by two helices, and a C-terminal excursion connecting the subunits. The active sites are located in a deep cleft between the subunits. The binding site of the flavin cofactor lacks the common nucleotide binding fold and is different from the FMN binding site found in flavodoxins. PubMed: 8846223DOI: 10.1038/nsb1295-1109 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.59 Å) |
Structure validation
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